The DeSoto Conference was formed in the Summer of 1953. The newly formed league began with seven original members in the south half of Mississippi. The Conference was formed just in time for the beginning of the fall football season.

         

DeSoto Conference Champions
1976		1964
1975	South Jones	1963	George County
1974		1962	Lumberton
1973	South Jones	1961	Petal
1972	Poplarville	1960
1971		1959
1970		1958
1969	George County	1957
1968		1956	Brooklyn
1967	George County	1955
1966	George County	1954
1965		1953	George County