The DeSoto Conference was formed in the Summer of 1953. The newly formed league began with seven original members in the south half of Mississippi. The Conference was formed just in time for the beginning of the fall football season.

         

DeSoto Conference Champions
1976		1964	George County
1975	South Jones	1963	George County
1974	South Jones	1962	Lumberton
1973	South Jones	1961	Petal
1972	Poplarville	1960	Lumberton
1971	Stone	1959	Poplarville
1970	Poplarville, Northeast Jones (Co-Champs)	1958	Notre Dame
1969	George County	1957	George County
1968	South Jones	1956	Brooklyn
1967	George County	1955	Poplarville
1966	George County	1954	George County
1965	Petal	1953	Poplarville