The Cherokee Conference was formed in 1965. The newly formed league began with five original members who would compete during that initial football season in the fall.
         

Cherokee Conference Champions
1980		1972
1979		1971
1978		1970	Scott Central
1977	Lake	1969
1976	Lake	1968
1975	Lake	1967	Lake
1974	Lake	1966	Lake
1973	Lake	1965	Beulah-Hubbard