| 1A Playoffs |
| 1st Round |
| 11/11/2022 (Fri) | | Biggersville 48-0 West Tallahatchie | | |
| 11/11/2022 (Fri) | | Simmons 54-0 Smithville | | |
| 11/11/2022 (Fri) | | McEvans 68-0 Ashland | | |
| 11/11/2022 (Fri) | | South Delta 24-6 Okolona | | |
| 11/11/2022 (Fri) | | Hamilton 31-10 Resurrection | | |
| 11/11/2022 (Fri) | | Taylorsville 50-0 Vardaman | | |
| 11/11/2022 (Fri) | | Bay Springs 64-0 Sebastopol | | |
| 11/11/2022 (Fri) | | West Lowndes 46-20 Lumberton | | |
| 2nd Round |
| 11/18/2022 (Fri) | | Biggersville 36-28 Simmons | | |
| 11/18/2022 (Fri) | | McEvans 34-8 South Delta | | |
| 11/18/2022 (Fri) | | Taylorsville 40-20 Hamilton | | |
| 11/18/2022 (Fri) | | Bay Springs 42-0 West Lowndes | | |
| Semi-finals |
| 11/25/2022 (Fri) | | McEvans 24-8 Biggersville | | |
| 11/25/2022 (Fri) | | Bay Springs 52-6 Taylorsville | | |
| Championship Game |
| 12/2/2022 (Fri) | | Bay Springs 22-0 McEvans | | |
| 2A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Collins 39-26 Loyd Star | | |
| 11/4/2022 (Fri) | | East Marion 35-6 North Forrest | | |
| 11/4/2022 (Fri) | | Lake 28-7 Pisgah | | |
| 11/4/2022 (Fri) | | Mize 41-0 Amite County | | |
| 11/4/2022 (Fri) | | Velma Jackson 55-0 Newton | | |
| 11/4/2022 (Fri) | | Heidelberg 34-14 Bogue Chitto | | |
| 11/4/2022 (Fri) | | Baldwyn 21-20 East Webster | | |
| 11/4/2022 (Fri) | | Northside 39-0 OBannon | | |
| 11/4/2022 (Fri) | | Eupora 43-14 Walnut | | |
| 11/4/2022 (Fri) | | George 28-26 Coahoma County | | |
| 11/4/2022 (Fri) | | Charleston 52-6 Leland | | |
| 11/4/2022 (Fri) | | East Union 38-12 Calhoun City | | |
| 11/4/2022 (Fri) | | Leflore County 40-6 Palmer | | |
| 11/4/2022 (Fri) | | Choctaw County 60-14 Belmont | | |
| 11/4/2022 (Fri) | | Philadelphia 48-21 Pelahatchie | | |
| 11/4/2022 (Fri) | | Scott Central 49-7 Nanih Waiya | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Choctaw County 33-0 Leflore County | | |
| 11/11/2022 (Fri) | | Northside 41-27 Baldwyn | | |
| 11/11/2022 (Fri) | | Lake 21-18 East Marion | | |
| 11/11/2022 (Fri) | | Eupora 37-12 George | | |
| 11/11/2022 (Fri) | | Charleston 24-14 Calhoun City | | |
| 11/11/2022 (Fri) | | Velma Jackson 14-7 Mize | | |
| 11/11/2022 (Fri) | | Philadelphia 27-14 Heidelberg | | |
| 11/11/2022 (Fri) | | Scott Central 55-7 Collins | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Eupora 58-18 Northside | | |
| 11/18/2022 (Fri) | | Scott Central 55-0 Philadelphia | | |
| 11/18/2022 (Fri) | | Velma Jackson 27-6 Lake | | |
| 11/18/2022 (Fri) | | Charleston 54-12 Choctaw County | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Charleston 24-6 Eupora | | |
| 11/25/2022 (Fri) | | Scott Central 32-7 Velma Jackson | | |
| Championship Game |
| 12/3/2022 (Sat) | | Scott Central 42-12 Charleston | | |
| 3A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Kossuth 42-0 Holly Springs | | |
| 11/4/2022 (Fri) | | Humphreys County 42-36 Aberdeen | | |
| 11/4/2022 (Fri) | | Independence 40-22 Booneville | | |
| 11/4/2022 (Fri) | | Noxubee County 39-14 Elzy | | |
| 11/4/2022 (Fri) | | Winona 43-7 Nettleton | | |
| 11/4/2022 (Fri) | | Water Valley 48-38 Rosa Fort | | |
| 11/4/2022 (Fri) | | Amory 53-7 Yazoo County | | |
| 11/4/2022 (Fri) | | North Panola 58-41 Mantachie | | |
| 11/4/2022 (Fri) | | Wesson 34-28 Union | | |
| 11/4/2022 (Fri) | | Tylertown 40-21 Perry Central | | |
| 11/4/2022 (Fri) | | Saint Stanislaus 45-14 Port Gibson | | |
| 11/4/2022 (Fri) | | Jefferson County 42-6 Seminary | | |
| 11/4/2022 (Fri) | | Magee 13-10 Enterprise Clarke | | |
| 11/4/2022 (Fri) | | Jefferson Davis County 48-6 Franklin County | | |
| 11/4/2022 (Fri) | | Hazlehurst 26-6 Clarkdale | | |
| 11/4/2022 (Fri) | | Raleigh 52-6 Morton | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Kossuth 41-14 Humphreys County | | |
| 11/11/2022 (Fri) | | Noxubee County 36-8 Independence | | |
| 11/11/2022 (Fri) | | Winona 48-14 Water Valley | | |
| 11/11/2022 (Fri) | | Amory 30-14 North Panola | | |
| 11/11/2022 (Fri) | | Wesson 33-19 Tylertown | | |
| 11/11/2022 (Fri) | | Raleigh 30-21 Saint Stanislaus | | |
| 11/11/2022 (Fri) | | Magee 36-26 Jefferson County | | |
| 11/11/2022 (Fri) | | Hazlehurst 32-13 Jefferson Davis County | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Noxubee County 32-10 Kossuth | | |
| 11/18/2022 (Fri) | | Amory 34-20 Winona | | |
| 11/18/2022 (Fri) | | Raleigh 56-28 Wesson | | |
| 11/18/2022 (Fri) | | Hazlehurst 32-14 Magee | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Noxubee County 52-51 Amory | OT | |
| 11/25/2022 (Fri) | | Raleigh 42-6 Hazlehurst | | |
| Championship Game |
| 12/2/2022 (Fri) | | Raleigh 55-52 Noxubee County | | |
| 4A Playoffs |
| 1st Round |
| 11/4/2022 (Fri) | | Quitman 42-21 McComb | | |
| 11/4/2022 (Fri) | | Moss Point 48-6 Forrest County AHS | | |
| 11/4/2022 (Fri) | | Poplarville 40-12 Pass Christian | | |
| 11/4/2022 (Fri) | | Newton County 31-7 Raymond | | |
| 11/4/2022 (Fri) | | Stone 41-6 Sumrall | | |
| 11/4/2022 (Fri) | | North Pike 12-0 Northeast Jones | | |
| 11/4/2022 (Fri) | | Itawamba AHS 38-6 Pontotoc | | |
| 11/4/2022 (Fri) | | Senatobia 17-16 Kosciusko | | |
| 11/4/2022 (Fri) | | Houston 31-14 Shannon | | |
| 11/4/2022 (Fri) | | West Lauderdale 26-20 Gentry | OT | |
| 11/4/2022 (Fri) | | Clarksdale 41-0 Choctaw Central | | |
| 11/4/2022 (Fri) | | Caledonia 21-18 New Albany | | |
| 11/4/2022 (Fri) | | Louisville 35-0 Greenwood | | |
| 11/4/2022 (Fri) | | Ripley 24-3 Corinth | | |
| 11/4/2022 (Fri) | | Mendenhall 40-0 Lanier | | |
| 11/4/2022 (Fri) | | Columbia 49-21 Greene Count | | |
| 2nd Round |
| 11/11/2022 (Fri) | | Itawamba AHS 42-14 Senatobia | | |
| 11/11/2022 (Fri) | | Stone 17-16 North Pike | OT | |
| 11/11/2022 (Fri) | | Houston 33-24 West Lauderdale | | |
| 11/11/2022 (Fri) | | Louisville 35-0 Ripley | | |
| 11/11/2022 (Fri) | | Mendenhall 29-20 Columbia | | |
| 11/11/2022 (Fri) | | Quitman 39-13 Moss Point | | |
| 11/11/2022 (Fri) | | Poplarville 49-21 Newton County | | |
| 11/11/2022 (Fri) | | Caledonia 26-0 Clarksdale | | |
| 3rd Round |
| 11/18/2022 (Fri) | | Mendenhall 34-0 Quitman | | |
| 11/18/2022 (Fri) | | Houston 26-22 Itawamba AHS | | |
| 11/18/2022 (Fri) | | Louisville 35-14 Caledonia | | |
| 11/18/2022 (Fri) | | Stone 32-28 Poplarville | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Louisville 31-21 Houston | | |
| 11/25/2022 (Fri) | | Mendenhall 26-14 Stone | | |
| Championship Game |
| 12/3/2022 (Sat) | | Louisville 17-14 Mendenhall | | |
| 5A Playoffs |
| 1st Round |
| 11/12/2022 (Sat) | | West Point 55-14 Holmes County Central | | |
| 11/12/2022 (Sat) | | Neshoba Central 27-2 Columbus | | |
| 11/12/2022 (Sat) | | Vicksburg 36-14 Cleveland Central | | |
| 11/12/2022 (Sat) | | Callaway 28-14 Lafayette | | |
| 11/12/2022 (Sat) | | Vancleave 41-35 Hattiesburg | | |
| 11/12/2022 (Sat) | | Gautier 38-21 Wayne County | | |
| 11/12/2022 (Sat) | | Picayune 24-9 Laurel | | |
| 11/12/2022 (Sat) | | West Jones 38-0 East Central | | |
| 2nd Round |
| 11/18/2022 (Fri) | | West Point 34-33 Neshoba Central | | |
| 11/18/2022 (Fri) | | Vicksburg 27-22 Callaway | | |
| 11/18/2022 (Fri) | | Gautier 42-21 Vancleave | | |
| 11/18/2022 (Fri) | | Picayune 28-17 West Jones | | |
| Semi-finals |
| 11/25/2022 (Fri) | | West Point 14-0 Vicksburg | | |
| 11/25/2022 (Fri) | | Picayune 49-14 Gautier | | |
| Championship Game |
| 12/2/2022 (Fri) | | Picayune 31-21 West Point | | |
| 6A Playoffs |
| 1st Round |
| 11/11/2022 (Fri) | | Starkville 38-12 Southaven | | |
| 11/11/2022 (Fri) | | Clinton 41-14 DeSoto Central | | |
| 11/11/2022 (Fri) | | Tupelo 42-0 Lewisburg | | |
| 11/11/2022 (Fri) | | Madison Central 30-21 South Panola | | |
| 11/11/2022 (Fri) | | Brandon 42-7 Hancock | | |
| 11/11/2022 (Fri) | | Warren Central 38-3 Gulfport | | |
| 11/11/2022 (Fri) | | Ocean Springs 49-21 Northwest Rankin | | |
| 11/11/2022 (Fri) | | Oak Grove 28-7 Biloxi | | |
| 2nd Round |
| 11/18/2022 (Fri) | | Starkville 30-2 Clinton | | |
| 11/18/2022 (Fri) | | Tupelo 28-7 Madison Central | | |
| 11/18/2022 (Fri) | | Brandon 36-28 Warren Central | | |
| 11/18/2022 (Fri) | | Ocean Springs 42-25 Oak Grove | | |
| Semi-finals |
| 11/25/2022 (Fri) | | Starkville 41-32 Tupelo | | |
| 11/25/2022 (Fri) | | Brandon 34-31 Ocean Springs | | |
| Championship Game |
| 12/3/2022 (Sat) | | Starkville 48-32 Brandon | | |
| MAIS-2A Playoffs |
| 1st Round |
| 10/28/2022 (Fri) | | Porters Chapel 36-30 Bens Ford LA | | |
| 10/28/2022 (Fri) | | Manchester Academy 48-0 Calhoun Academy | | |
| 10/28/2022 (Fri) | | Prentiss Christian 54-42 Columbus Christian | | |
| 10/28/2022 (Fri) | | Christian Collegiate Academy 63-12 Prairie View LA | | |
| 2nd Round |
| 11/4/2022 (Fri) | | Tunica Academy 42-0 Porters Chapel Academy | | |
| 11/4/2022 (Fri) | | North Sunflower Academy 22-20 Manchester Academy | | |
| 11/4/2022 (Fri) | | Tallulah LA 42-16 Prentiss Christian | | |
| 11/4/2022 (Fri) | | Newton County Academy 40-34 Christian Collegiate Academy | | |
| Semi-finals |
| 11/11/2022 (Fri) | | Tunica Academy 64-44 North Sunflower Academy | | |
| 11/11/2022 (Fri) | | Tallulah LA 52-30 Newton County Academy | | |
| Championship Game |
| 11/17/2022 (Thu) | | Tunica Academy 46-6 Tallulah LA | | |
| MAIS-3A Playoffs |
| 1st Round |
| 10/28/2022 (Fri) | | Benton Academy 21-6 Delta Streets Academy | | |
| 10/28/2022 (Fri) | | Sylva-Bay Academy 56-0 Rossville Christian TN | | |
| 2nd Round |
| 11/4/2022 (Fri) | | Greenville Christian 42-0 Benton Academy | | |
| 11/4/2022 (Fri) | | Central Holmes Christian 35-12 Amite | | |
| 11/4/2022 (Fri) | | Canton Academy 48-6 Sylva-Bay Academy | | |
| 11/4/2022 (Fri) | | Centreville Academy 52-26 Winona Christian | | |
| Semi-finals |
| 11/11/2022 (Fri) | | Central Holmes Christian 33-32 Greenville Christian | | |
| 11/11/2022 (Fri) | | Canton Academy 42-8 Centreville Academy | | |
| Championship Game |
| 11/23/2022 (Wed) | | Canton Academy 47-14 Central Holmes Christian | | |
| MAIS-4A Playoffs |
| 1st Round |
| 10/28/2022 (Fri) | | Winston Academy 36-0 Marshall Academy | | |
| 10/28/2022 (Fri) | | Tri-County Academy 35-0 Indianola Academy | | |
| 10/28/2022 (Fri) | | Carroll Academy 28-14 Bowling Green LA | | |
| 10/28/2022 (Fri) | | Riverfield LA 42-22 Clinton Christian | | |
| 2nd Round |
| 11/4/2022 (Fri) | | Adams Christian 15-14 Winston Academy | | |
| 11/4/2022 (Fri) | | Tri-County Academy 35-0 Lee Academy | | |
| 11/4/2022 (Fri) | | Saint Joseph Greenville 48-0 Carroll Academy | | |
| 11/4/2022 (Fri) | | Riverfield LA 23-22 Brookhaven Academy | | |
| Semi-finals |
| 11/11/2022 (Fri) | | Tri-County Academy 28-21 Adams Christian | | |
| 11/11/2022 (Fri) | | Saint Joseph Greenville 46-0 Riverfield LA | | |
| Championship Game |
| 11/17/2022 (Thu) | | Saint Joseph Greenville 26-14 Tri-County Academy | | |
| MAIS-5A Playoffs |
| 1st Round |
| 10/28/2022 (Fri) | | Pillow Academy 31-28 Silliman LA | | |
| 10/28/2022 (Fri) | | Oak Forest LA 35-6 Bayou Academy | | |
| 10/28/2022 (Fri) | | Leake Academy 41-7 Starkville Academy | | |
| 10/28/2022 (Fri) | | Saint Joseph Madison 34-31 Lamar | | |
| 2nd Round |
| 11/4/2022 (Fri) | | Heritage Academy 48-21 Pillow Academy | | |
| 11/4/2022 (Fri) | | Oak Forest LA 34-7 Magnolia Heights | | |
| 11/4/2022 (Fri) | | Copiah Academy 47-6 Leake Academy | | |
| 11/4/2022 (Fri) | | Simpson Academy 34-26 Saint Joseph Madison | | |
| Semi-finals |
| 11/11/2022 (Fri) | | Oak Forest LA 45-33 Heritage Academy | | |
| 11/11/2022 (Fri) | | Simpson Academy 13-10 Copiah Academy | | |
| Championship Game |
| 11/23/2022 (Wed) | | Oak Forest LA 24-14 Simpson Academy | | |
